Clinical testing using various array comparative genomic hybridization platforms is being incorporated rapidly into cytogenetic testing algorithms. Comprehensive validation of these complex assays ...

为探究儿童急性淋巴细胞白血病（ALL）的发病机制，研究人员对 67 例马来西亚正常核型的儿童 ALL 患者开展基于阵列比较基因组杂交（array-CGH）研究。结果发现了致病性拷贝数变异（CNVs）和意义不明变异（VUS），这有助于白血病分类和个性化治疗123。 儿童急性 ...

The introduction of array comparative genome hybridization (CGH) into prenatal genetic diagnosis presents both challenges and controversy to the clinical cytogenetic community. The challenges are ...

In addition to the surprising revelation that our chromosomes harbor fewer genes than originally predicted, the Human Genome Project also unveiled that all individuals share approximately 99.9% of ...

Early efforts to examine genomic changes in the clinical setting relied on cytogenetic techniques such as chromosome karyotyping, a widely used approach to examine chromosomes and identify changes ...