在一项新的研究中，研究人员组合使用基因编辑技术和干细胞技术，鉴定出我们的免疫系统中的两个基因IRF5和IL-10RA在抵抗衣原体感染中发挥着关键性的作用。这些结果为治疗由衣原体导致的这种性传播疾病鉴定出新的药物靶标。

准确且灵敏的分子检测是现代临床诊断和精准医学的基础。CRISPR/Cas系统的出现彻底改变了核酸检测的方式，为临床生物标志物 ...

The cryogenic electron microscope structure of the A4p-activated (green) CalpL protein filament (violet) from Candidatus Cloacimonas acidaminovorans (PDB ID: 9EYJ). CRISPR-Cas systems help to protect ...

Gene editing in plants remains challenging, with the traditional non-homologous end-joining (cNHEJ) repair pathway often hindering precision. In this study, researchers advanced CRISPR-Cas-based gene ...

Out of the many challenges scientists face in bringing genomic medicine to patients, delivery is near the top of the list. Due to these barriers in getting the genetic payload to the correct target ...

Another potentially game-changing discovery has come out of the lab of Feng Zhang, PhD. This time, they uncovered the first programmable RNA-guided system in eukaryotes. Just a few months ago, the ...

细菌与噬菌体之间的军备竞赛已经持续了数十亿年。这场没有硝烟的战争催生了地球上最复杂、最精巧的防御系统。当我们以为自己已经通过Cas9、Cas12a或Cas13窥探到了CRISPR-Cas系统的全貌时，自然界总能以一种令人惊叹的方式提醒我们：我们所知的，不过是冰山一角。