Explore scalable strategies for iPSC-derived islet differentiation using GMP-grade activin A and KGF to advance diabetes ...

A comprehensive map of aberrant hematopoiesis in people with acute myeloid leukemia defines specific cell states and potential therapeutic targets. The team used their reference map for normal ...

Metabolic diseases such as obesity, fatty liver, and insulin resistance are rapidly increasing worldwide, but fundamental ...

The Notch signaling pathway plays a pivotal role in determining cell fate, especially in the development and function of T cells. But mimicking this highly mechanical, contact-dependent pathway in the ...

T cells sit at the center of modern immunotherapy, yet many of the rules that govern their activation, differentiation, dysfunction (e.g., exhaustion), and ...

Type 1 diabetes (T1D) is an autoimmune disorder characterized by the specific destruction of insulin-producing pancreatic ...

Cells operate on rules not vibes, including when on the precipice of persisting or perishing. Yet, with prior research ...

In experiments with mice, Johns Hopkins Medicine scientists report new evidence that precursors of myelin-producing cells—one ...

Researchers have developed a way to grow a highly specialized subset of brain nerve cells that are involved in motor neuron ...

A research team has developed a way to produce a subset of highly specialised brain neurons that centrally degenerate in motor neuron disease and are damaged in spinal cord injury, laying foundations ...