This important study introduces a new biology-informed strategy for deep learning models aiming to predict mutational effects in antibody sequences. It provides solid evidence that separating ...

Experiments on an ultra-rare genetic mutation that causes neurodegeneration in children have helped uncover a new mechanism by which brain cells die. The findings raise the possibility that similar ...

This study offers important insight into the pathogenic basis of intragenic frameshift deletions in the carboxy-terminal domain of MECP2, which account for some Rett syndrome cases, yet similar ...

A single modification in the protein found on the surface of the highly pathogenic avian influenza (HPAI) H5N1 influenza virus currently circulating in U.S. dairy cows could allow for easier ...

Receptor binding site of the A/Texas/37/2024 hemagglutinin Leu226 mutant (yellow) in complex with the human receptor analog LSTc (cyan). LA JOLLA, CA—Avian influenza viruses typically require several ...

Researchers have discovered new regions of the human genome particularly vulnerable to mutations. These altered stretches of DNA can be passed down to future generations and are important for how we ...

Unique mutations in the H5N1 strain enhance replication in human cells and cause severe disease in mice. The virus has spread from birds to mammals, including dairy cows, and infected humans, with one ...

Dozens of people in the United States have caught bird flu from animals this year, but there's no evidence that the viral disease has spread from one person to another. However, a single mutation in ...

Concern surrounding the highly pathogenic avian influenza H5N1 influenza virus currently circulating in dairy cows in the United States is growing. A total of 58 human cases have been reported as of ...

A single modification in the protein found on the surface of the highly pathogenic avian influenza (HPAI) H5N1 influenza virus currently circulating in U.S. dairy cows could allow for easier ...