After treatment, the mice’s memories were essentially shunted back into a younger state. The researchers found that reprogrammed engrams displayed molecular behavior of more youthful cells. Using a ...

Age-related memory decline and neurodegenerative diseases like Alzheimer's are often thought of as irreversible. But the brain is not static; neurons continually adjust the strength of their ...

Boosting mitochondrial calcium by inhibiting the LETM1 protein enhances long-term memory formation in flies and mice.

An international team led by Jaime de Juan-Sanz at the Paris Brain Institute has shown that slightly increasing the metabolic capacity of neurons can enhance long-term memory in both fruit flies and ...

Memories can form outside of the brain, according to new research. Non-brain cells exposed to chemical pulses similar to the ones that brain cells are exposed to when presented with new information ...

Previous work from the Chandel laboratory had demonstrated mitochondrial ETC function was required for the proliferation of CD8 + T-cells, immune cells that help fight cancer and viral infection by ...

Memory T cells are a special type of white blood cell that "remember" past infections and vaccines, helping our bodies to quickly respond if we encounter the same germs again. These cells are found ...

A multi-institutional study has mapped the genetic circuitry that determines whether CD8 killer T cells become durable immune defenders or lapse into exhaustion, and has shown that disabling two ...

However, details of the intervening steps, as researchers have learned in the past 65 years, are quite complex — certain cells carry the flu antigen to the immune system, specific immune cells respond ...