Patch-clamp recordings demonstrated that LHON neurons, which typically exhibit impaired sodium and potassium currents, showed restored electrophysiological function after co-culture with MSCs.

Mitochondria are semi-autonomous organelles containing their own DNA (mtDNA), which exhibits a higher mutation rate compared to nuclear DNA. Accumulation of mtDNA mutations is associated with aging ...

Pretzel Therapeutics is advancing its mitochondrial disease therapies, pushing lead candidate PX578 through Phase 1 trials ...

Scientists have discovered how a mitochondrial mutation rewires immune function in a model of inherited primary mitochondrial disorders, which often lead to severe disability and death. They have ...

The tiny little powerhouses of our cells, the mitochondria, are unique among organelles because they carry their own tiny ...

A previously unknown type of DNA damage in the mitochondria, the tiny power plants inside our cells, could shed light on how our bodies sense and respond to stress. The findings of the UC ...

Scraps of DNA discarded by our neurons' power units are being absorbed into our nuclear genome far more frequently than assumed, potentially putting our brains at greater risk of developing ...