Phosphoinositide 3-kinases (PI3Ks) are involved in many vital cell functions and their dysregulation has been implicated in the pathology of various disorders. Pharmacological and genetic studies have ...

DUBLIN--(BUSINESS WIRE)--The "Copiktra" report has been added to ResearchAndMarkets.com's offering. Copiktra (duvelisib; Verastem/Yakult Honsha) is a highly selective small molecule inhibitor of the ...

Targeted therapy with imatinib has transformed the treatment of chronic myeloid leukemia (CML). Unlike CML, chronic lymphocytic leukemia (CLL) lacks a common genetic aberration but does demonstrate ...

皮肤黑色素瘤（SKCM）中COMMD4通过调控PI3K-AKT通路和上皮-间质转化促进肿瘤进展，三聚氰胺可有效抑制其作用。 摘要 皮肤黑色素瘤（SKCM）是全球最具侵袭性的皮肤恶性肿瘤，其分子驱动机制仍知之甚少。尽管铜代谢相关蛋白家族MURR1结构域（COMMD）与肿瘤发生 ...

Myriad of Groups Are Working on the Latest Hot Target and Most Are Optimistic About Its Potential Although the term “signal transduction” was coined back in 1972, cell-signaling switches have only ...

INDIANAPOLIS, April 5, 2011 (GLOBE NEWSWIRE) -- Semafore Pharmaceuticals today announced encouraging preclinical results for its lead product candidate, SF1126, in certain B-cell malignancies. The ...