Compared to other enzyme families such as cytochromes P450, pharmacogenetic studies of human sulfotransferases (SULTs) in relation to drug response are fairly limited. Previously, human platelets have ...

On average, a drug on the market works effectively for only 50% of the people who take it. Would you want to prevent a potential adverse drug effect or even toxicity through a simple test? It's not ...

In the late 1990s and early 2000s, healthcare providers and researchers noticed that some patients with HIV (approximately 5%) experienced a severe hypersensitivity reaction to the drug abacavir, in ...

Genetically selected medicine has been much hyped but has significant potential. Regulation and treatment will depend on pharmaceutical companies more readily sharing genetic data. We all know someone ...

Technical hurdles to the wide-spread use of genetic data in humans are disappearing. The cost of sequencing an entire human genome is sinking to around $1,000. Commercial companies are offering ...

For decades, genotyping has promised to serve as a practical means of relating genetic make-up and pharmacological efficiency—first at the level of patient groups and more recently at the level of ...

Mutational Signature and Transcriptomic Classification Analyses as the Decisive Diagnostic Tools for a Cancer of Unknown Primary The Michigan Oncology Sequencing (MI-Oncoseq) program at The University ...

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in ...

Combinatorial pharmacogenetics-guided treatment did not demonstrate improved outcomes compared to treatment-as-usual in adolescents with depression, and future research should examine specific ...

From the perspective of current and future patients, the development of the field of pharmacogenetics is of immense interest. The encouraging vision that is now being ...