本研究针对真核生物mRNA和lncRNA 3'末端多聚腺苷酸化位点(PAS)注释不全面、存在内部引物伪影等问题，开发了PolyA_DB v4数据库。团队通过深度挖掘364个人类与451个小鼠3'READS+数据集（约23亿条PAS支持 reads），结合长读长RNA测序(LR-RNA-seq)验证，分别鉴定出142.9万（人 ...

Harold Widom, professor emeritus of mathematics at the University of California, Santa Cruz, will share the prestigious George Pólya Prize with UC Davis professor of mathematics Craig Tracy. The two ...

In TDP-43 proteinopathies, such as frontotemporal dementia, amyotrophic lateral sclerosis, and limbic predominant age-related TDP-43 encephalopathy, the notorious RNA binding protein abandons its post ...