CLEVELAND, March 06, 2023 (GLOBE NEWSWIRE) -- NovelMed Therapeutics announced today that NM3086, the lead clinical asset in its Properdin-associated Alternative Pathway (AP) program, demonstrated ...

Two functions have been assigned to properdin; stabilization of the alternative convertase, C3bBb, is well accepted, whereas the role of properdin as pattern recognition molecule is controversial. The ...

Dysregulation of the complement cascade is implicated in the pathogenesis of several inflammatory and allergic disorders, such as arthritis, ischaemia–reperfusion injury and asthma. In a study ...

CLEVELAND, June 05, 2023 (GLOBE NEWSWIRE) -- NovelMed Therapeutics, Inc. announced today topline results from First-in-Human Phase I clinical trial of its complement blocker monoclonal anti-Properdin ...

The observations shown in Table 1 were designed to assess the relative role of properdin and ‘0° factor’ in native and poly I enhanced PNHE lysis, and to compare the stimulating effect of poly I on ...

Novelmed Therapeutics Inc. has reported topline results with its lead anti-properdin antibody NM-3086 in a rabbit model of paroxysmal nocturnal hemoglobinuria (PNH). NM-3086 is a potent, ...

NM5072 is a potential first-in-class monoclonal antibody that selectively blocks properdin, a protein of the complement alternative pathway. The Food and Drug Administration (FDA) has granted Orphan ...

After seven years of intense research, a research group from Aarhus University has succeeded - through an interdisciplinary collaboration - in understanding why a very extended structure is important ...

New research assigns hitherto unappreciated importance to a protein of the body's immune defense system. The research has helped to advance medical understanding of how the body defends against ...

A research group has succeeded in understanding why a very extended structure is important for an essential protein from the human immune system. The new results offer new opportunities for adjusting ...

We are at a critical time and supporting climate journalism is more important than ever. Science News and our parent organization, the Society for Science, need your help to strengthen environmental ...

A University of Leicester researcher has discovered how a protein in the blood – linked to defence against meningitis - plays a more vital role than previously understood in the body’s immune defence ...