Protein engineering is a powerful biotechnological process that focuses on creating new enzymes or proteins and improving the functions of existing ones by manipulating their natural macromolecular ...

Reporting in Science, researchers at UC Santa Barbara, UCSF and the University of Pittsburgh have developed a new workflow for designing enzymes from scratch, paving the way toward more efficient, ...

From growth hormones to cancer drugs, small molecules play a crucial role in our health. Monitoring them is essential to keeping us healthy; it enables physicians to calculate dosages and patients to ...

Textbooks often depict proteins in one conformation, but real life, as usual, is much messier. While some proteins have stable, unchanging structures, many others have intrinsically disordered regions ...

Understanding the structure of proteins is critical for demystifying their functions and developing drugs that target them. To that end, a team of researchers at Brown University has developed a way ...

An international research team reveals new molecular mechanisms associated with pathogenic mutations in the protein transthyretin that cause ...

A multicolored 3D model of an enzyme binding double-stranded DNA against a light purple background Computational enzyme design could allow for reactions not seen in nature. Credit: Ian Haydon ...

The “ChatGPT moment” for biology proceeds to unfold as protein language models, or machine learning tools trained on large databases of protein sequences, work to decode the language of life with the ...

Three scientists were named winners of the 2024 Nobel Prize in Chemistry for their innovations in the fields of computational protein design and structure prediction. One half of the prize was awarded ...