随着RNA修饰（如m6A、Ψ）被证实广泛参与基因调控与疫苗开发，其系统性研究仍面临巨大挑战。尽管已发现170余种修饰，但当前主流基于二代测序的检测方法通量低，一次实验仅能检测一种类型。以牛津纳米孔直接RNA测序为代表的第三代技术，因其无需扩增、可同时检测多种修饰的潜力，成为破局关键。目前绝大多数工具仅针对m6A设计，存在性能差异大、对新数据支持不足、多类型修饰识别易混淆等局限。因此，对现有工具进行 ...

传统认知中，MYC是驱动癌细胞无限增殖的“总开关”——它作为转录因子，结合在DNA上，对大量基因的表达产生积极影响，形成肿瘤的特征性表达谱。除此之外，MYC还可以帮助癌细胞逃避免疫系统的监视：在胰腺癌模型中，敲除MYC能引发肿瘤消退，但这种效应在免疫 ...

Years of experiments and databases filled with RNA-seq results belie the simple reality that, until fairly recently, it was impossible to analyze RNA directly. The RNA-seq studies performed with ...

RNA sequencing has emerged as a powerful supplement to DNA sequencing for Mendelian disease diagnosis, but clinical translation of diagnostic RNA-seq has not been widely achieved. Researchers at ...

The discovery of catalytic RNA transformed our understanding of life's beginnings. Clare Sansom explores how the RNA world ...

Life on Earth may have started with a molecule that still runs our cells today. As researchers probe ribonucleic acid in the ...

According to research from a team at the University of Utah Health and the University of Nevada, Reno School of Medicine, ...

By adding AI-enabled RNA design and active learning, Eclipsebio extends its sequencing-based analytics platform into a fully ...

Increasing paternal age has been linked to elevated health risks for the next generation, including higher risks of obesity ...