In the 1990s, a number of new chemotherapeutic agents such as the taxanes, vinorelbine, gemcitabine, and irinotecan were introduced into the management of advanced non-small-cell lung cancer (NSCLC).

编者按慢加急性肝衰竭（ACLF）作为一种危重临床综合征，其典型特征是在慢性肝病基础上出现急性恶化，并伴随多器官功能衰竭，死亡率极高。尽管粒细胞集落刺激因子（G-CSF）曾被提议作为ACLF的潜在治疗方法，但其临床疗效一直存在较大争议。值得注意的是，此 ...

Schizophrenia is a common, chronic and disabling neuropsychiatric disorder, affecting about 1% of the world's population. 1 It is a complex disorder that is likely to result from the interaction of ...

In a recent study published in Jama Network, researchers investigated the impact of coronavirus disease 2019 (COVID-19) on biomarkers in the cerebrospinal fluid (CSF). Study: Viral Antigen and ...

The data for this retrospective observational study were obtained from the electronic health records (EHRs) of patients with colorectal cancer who received chemotherapy at Texas Oncology. The EHR ...

GM-CSF Knock-out CAR-T Study Published in Peer-Reviewed Journal Leukemia CRISPR/Cas9-Mediated GM-CSF knock-out (GM-CSF ko) CAR-T cells demonstrate reduced apoptosis and enhanced in vivo anti-tumor ...

Researchers from the MPI of Biochemistry and the Technical University of Munich have discovered new diagnostic markers for multiple sclerosis (MS), a disease that affects 3 million people worldwide.

Impact of Broadening Trial Eligibility Criteria on the Inclusion of Patients With Brain Metastases in Cancer Clinical Trials: Time Series Analyses for 2012-2022 Effective diagnosis, prognostication, ...

Cerebrospinal fluid (CSF) analysis has perhaps the strongest diagnostic and prognostic potential for Alzheimer disease to date, yet some think the field is not harnessing its full power because ...

A multitude of genes have been linked to the development of Alzheimer’s disease. Specifically how those genes might influence the progression of neurodegeneration remains something of a black box ...

The apolipoprotein E4 (ApoE4) allele, the strongest known genetic risk factor for late-onset sporadic Alzheimer’s disease, puts women at higher risk for the disease than men, but how remains unclear.