New research from Oregon Health & Science University for the first time reveals the function of a little-understood junction between cells in the brain that could have important treatment implications ...

A biomimetic synapse built from water droplets and biological ion channels achieves synaptic plasticity and performs machine learning tasks.

An interdisciplinary team of scientists at the Max Planck Florida Institute for Neuroscience have developed a novel approach to measure the activity and strength of individual synapses that drive a ...

Late-life depression is a major risk factor for Alzheimer's disease, in particular because it accelerates progression from mild cognitive impairment to dementia. How this happens remains largely ...

Synapses are the connections between neurons that allow them to communicate with one another. In all cells, including neurons, protein molecules are the main actors who carry out the cell's work.

The death of synapses, and the neurons that need them, marks the inevitable endgame of Alzheimer’s disease. Despite this eventual synaptic mayhem, a new work, led by Thomas Südhof and Marius Wernig at ...

Family with sequence similarity 19 member A5 (FAM19A5) is a secretory protein highly expressed in the brain that regulates synapse dynamics through its interaction with leucine-rich repeat-containing ...

Clinical portfolio, informed by deep and novel synapse biology and pharmacology insights, aims to strengthen neural connections through event-driven pharmacology Lead candidate zelquistinel is ...