In neurons as well as other eukaryotic cells, intracellular proteins are primarily degraded by the ubiquitin–proteasome system (UPS), and membrane proteins by the lysosome system. Ubiquitylation tags ...

Figure 1: HDAC6 rescues degeneration in flies with proteasome impairment and in a fly model of SBMA that exhibits impaired UPS function. Figure 2: Induction of compensatory autophagy in flies with ...