*仅供医学专业人士阅读参考最近这一个月，围绕DNA修复的重磅研究非常多。10月中旬，同济大学团队发表在《科学》杂志上的论文显示，裸鼹鼠在进化过程中，替换了cGAS蛋白的四个氨基酸，将其从抑制DNA修复转变为增强DNA修复[1]。这也保证裸鼹鼠健康长寿 ...

本研究系统揭示了DNA双链断裂修复后的一个被长期忽视的层面：染色质结构与基因功能的不可逆改变。这种结构性与功能性损伤可稳定地传递给子代细胞，形成一种可遗传的基因表达缺陷，被作者定义为“染色质疲劳（chromatin fatigue）”。染色质疲劳为理解细胞老化、癌症发生、环境应激应答及基因编辑潜在副作用提供了新的理论框架，也提示未来在研究DNA修复及基因治疗时，必须同时关注三维染色质层面的长期影响 ...

Alcohol consumption leads to the formation of a toxic compound called acetaldehyde, which damages DNA. A research team from ...

In a new study, scientists at the Max Planck Institute for Evolutionary Anthropology in Leipzig analyzed the impact of more ...

Cedars-Sinai scientists have created a new experimental drug called TY1 that helps the body repair damaged DNA and restore ...

The researchers focused on Fanconi anemia, a rare inherited disorder characterized by a failure to repair specific types of ...

DNA can sustain serious injuries called double strand breaks, in which both strands of the helix snap. These breaks are among ...

After two decades in the making, scientists have cracked the code on a drug that can repair DNA, setting the scene for a new ...

The DNA inside our cells is constantly being damaged, and one of the worst kinds of damage is a double-strand break—when both ...

When DNA breaks, cells must repair it accurately to prevent harmful mutations. Researchers have discovered that during a key ...