慢性疼痛与抑郁共病是临床治疗难题，现有药物疗效有限。本文研究了α-(苯基硒烷基)苯乙酮（PSAP）在小鼠神经性疼痛合并抑郁模型中的作用。研究发现，PSAP不仅能有效逆转疼痛超敏和抑郁样行为，还能通过其抗氧化、抗炎特性及调控NF-κB p65/TNF-α/IDO通路和恢复 ...

帕金森病（PD）机制不明难以治疗。研究人员开展了关于少突胶质细胞在 PD 发病机制中作用的研究。结果发现少突胶质细胞通过 PSAP-GPR37-IL-6 轴驱动 PD 样神经退行性变，该轴可作为潜在治疗靶点，为 PD 治疗提供新方向。 帕金森病，这个名字想必大家或多或少都 ...

Figure 2: PGRN facilitates uptake and lysosomal targeting of PSAP in primary cortical neurons. Figure 4: Increased levels of PGRN and PSAP in activated glial cells on injury. Figure 7: PSAP levels are ...

Figure 2: Functional analysis of rs7869-dependent regulation of PSAP and PGRN levels. Figure 4: PSAP knockdown does not affect TFEB localization and increases extracellular PGRN more robustly than ...

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