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Nature Biotechnology | 单轮进化的奇迹:GRAPE-LM 如何重塑 RNA 适配体的发现 ...
引言生物分子的定向进化 (Directed Evolution) 长期以来被视为一种模拟自然选择的艺术。无论是蛋白质还是核酸,通过迭代筛选获得功能分子的过程,往往意味着数周甚至数月的高强度实验。尤其是对于 RNA 适配体 (RNA Aptamers) 而言,传统的指数富集配体系统进化技术 (SELEX) ...
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