Contributed by Howard Y. Chang; received November 19, 2024; accepted February 20, 2025; reviewed by Jellert Gaublomme and David A. Quigley The spatial organization of cells within tissues plays a ...

Background Intraductal papillary mucinous neoplasms (IPMNs) are precursor lesions of pancreatic cancer with highly variable malignant potential. Current understanding of their biology remains ...

New simulator and computational tools generate realistic ‘virtual tissues’ and map cell-to-cell ‘conversations’ from spatial transcriptomics data, potentially accelerating AI-driven discoveries in ...

Foster City, Calif. | January 27, 2026 — Signios Bio today announced the launch of a new grant program supporting innovative spatial transcriptomics research using the 10x Genomics Xenium 5K Spatial ...

Biological systems are inherently three-dimensional—tissues form intricate layers, networks, and architectures where cells interact in ways that extend far beyond a flat plane. To capture the true ...

Abstract: Recent advancements in spatial transcriptomics technology have enabled the capture of gene expression profiles while maintaining spatial information. Accurately identifying spatial ...

The tumor microenvironment (TME) of invasive lobular carcinoma (ILC) remains largely unexplored despite its clinical relevance and distinct biology. Using spatial transcriptomics, we reveal insights ...

Neoadjuvant immunotherapy in combination with chemotherapy in resectable locally advanced head and neck squamous cell carcinoma: A randomized, open label, phase II clinical trial. This is an ASCO ...

As life sciences enter the era of precision biology, spatial genomics and transcriptomics are transforming our ability to decode gene expression not just at the molecular level, but also within the ...

Spatial metabolomics is rapidly advancing, with new spatial multi-omics workflows emerging that integrate spatial metabolomics with transcriptomics or proteomics. SpatialData, as an infrastructure ...