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Serious Risks of Reflux Esophagitis Reflux esophagitis, a condition where stomach acid flows back up into the esophagus, can lead to significant complications if left untreated. Here are some of the most serious risks: Barrett's esophagus: This is a precancerous condition where the lining of the esophagus changes to resemble the lining of the intestine. This change is caused by chronic exposure to stomach acid. People with Barrett's esophagus have a higher risk of developing esophageal cancer. E